rifapentine will reduce the extent or effect of sildenafil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. Potent CYP3A4 inducers are envisioned to lead to considerable decreases in sildenafil plasma stagesContraindicated (one)nirmatrelvir will boost the stage or effect of sildenafil by impacting hepatic/intestinal en